Klebsiella pneumoniae rezistences noteikšana pret beta-laktāmu grupas antibakteriālajiem līdzekļiem

6533b7dcfe1ef96bd1272ea2

RESEARCH PRODUCT

Klebsiella pneumoniae rezistences noteikšana pret beta-laktāmu grupas antibakteriālajiem līdzekļiem

subject

PCR ESBL K.pneumoniae β-laktāmi Farmācija rezistence

description

Pret β-laktāmiem rezistentā K.pneumoniae izraisa nozokomiālās infekcijas, kuras nepakļaujas terapijai, pagarina slimošanas laiku, palielina finansiālo slogu un nāves risku, kā arī rada problēmas efektīvā antibakteriālās terapijas izvēlē nākotnē. Darba mērķis ir apkopot un analizēt datus par K.pneumoniae rezistences izmaiņām 3 gadu periodā. Jutība pret β-laktāma, aminoglikozīdu un hinolonu grupas antibiotikām tika noteikta, izmantojot disku difūzijas testu un E-testu. Karbapenemāzes producējošos celmus noteica ar Hodge testu, ESBL – ar dubultdisku metodi. Izolēti 588 K.pneumoniae celmi ar prevalenci 2017.gadā (5,8%). 10,71% no izolātiem bija ESBL producētāji. Rezultāti liecina, ka 2015. un 2017.gadā dominē rezistence pret ceftazidīmu (11,9% un 8,0%), 2016.gadā – pret ciprofloksacīnu (19,0%). 2016. un 2017.gadā visi celmi bija jutīgi pret karbapenēmiem. Secināts, ka arvien biežāk tiek izdalīti K.pneumoniae izolāti, tomēr nav novērojams rezistento, karbapenemāžu un ESBL producējošo baktēriju skaita pieaugums.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/40237

PEPhysical Sciences and Engineering
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