Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.

6533b7dcfe1ef96bd12734c0

RESEARCH PRODUCT

Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.

Manlio Tolomeo Stefania Grimaudo Giuseppina Grisolia Riccardo Baruchello Sabrina Cavallini Daniele Simoni And Antonietta Di Cristina Vincenzo Abbadessa Francesco Paolo Invidiata Nicola Gebbia Riccardo Rondanin Anna Siniscalchi Marinella Roberti Silvia Marino Lucia Crosta Giuseppe Giannini Marcello Rossi Stefania Aiello

subject

Programmed cell death Necrosis receptor-alpha medicine.drug_class mechanism Apoptosis HL-60 Cells necrosis chemistry.chemical_compound Retinoids death Terphenyl Drug Discovery medicine Humans Retinoid Neurons Cell growth biphenyl-4-carboxylic acid arotinoid In vitro Cell biology Cultured cortical-neuron chemistry Biochemistry Cell culture Apoptosis retinobenzoic acid Molecular Medicine Indicators and Reagents multidrug medicine.symptom Cell Division (14R)-14-hydroxy-4 14-retro-retinol

description

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

year	journal	country	edition	language
2005-01-01	Journal of medicinal chemistry

10.1021/jm049080y https://pubmed.ncbi.nlm.nih.gov/15974583

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