6533b7dcfe1ef96bd127351f
RESEARCH PRODUCT
Interaction of Human Phagocytes with Pigmentless Aspergillus Conidia
Gerhard WannerBernhard JahnJohannes LotzAxel A. BrakhageFatima BoukhalloukKim Langfeldersubject
ImmunologyVirulencemedicine.disease_causeMicrobiologyAspergillus nidulansConidiumAspergillus fumigatusMicrobiologyMultienzyme ComplexesAspergillus nidulansmedicineskin and connective tissue diseaseschemistry.chemical_classificationPhagocytesAspergillusReactive oxygen speciesbiologyAspergillus fumigatusfungiFungal geneticsFree Radical ScavengersPigments BiologicalSpores FungalOxidantsbiology.organism_classificationInfectious DiseaseschemistryParasitologysense organsFungal and Parasitic InfectionsOxidative stressdescription
ABSTRACT A defect in the pksP gene of Aspergillus fumigatus is associated with the loss of conidial pigmentation, a profound change of the conidial surface structure, and reduced virulence. The structural change of the conidial surface structure was not observed in similar A. nidulans wA mutants. Our data indicate that the pigment of both species is important for scavenging reactive oxygen species and for protection of conidia against oxidative damage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-06-01 | Infection and Immunity |