6533b7ddfe1ef96bd127365e
RESEARCH PRODUCT
Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications
Paolo ArmanettiIlaria MonacoErica LocatelliAndrea PaceMirko MaturiLuca MenichettiAlessandra FloriAntonio Palumbo Piccionellosubject
Fluorescent nanoparticleMaterials scienceAtomic and Molecular Physics and OpticDopamineMagnetic nanoparticleIron oxideNanoparticleNanotechnologyBioengineering02 engineering and technology010402 general chemistry01 natural scienceschemistry.chemical_compoundGeneral Materials ScienceChemistry (all)technology industry and agricultureSettore CHIM/06 - Chimica OrganicaGeneral Chemistry021001 nanoscience & nanotechnologyCondensed Matter PhysicsFluorescenceAtomic and Molecular Physics and Optics0104 chemical scienceschemistryTargeted drug deliveryDual-imagingModeling and SimulationDrug deliveryDrug deliverySurface modificationMagnetic nanoparticlesMaterials Science (all)0210 nano-technologyIron oxide nanoparticlesdescription
A selective functionalization of dopamine amino group with the photoluminescent 7-nitroben-zofurazan was achieved through a one-pot protection-functionalization-deprotection sequence. The resulting fluorescent catecholic ligand was used as a capping agent for iron oxide nanoparticles thus obtaining photoluminescent magnetic nanoparticles (PL-MNPs). The PL-MNPs were then embedded into PLGA-b-PEG polymeric nanocarriers which quenched the emission of the capping agent. Full recovery of fluorescence was observed after disassembling the polymeric layer of the nanoparticle, thus supporting the use of PL-MNPs as a multifunctional system for targeted drug delivery.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-09-24 |