Izmaiņas neironu mielinizācijas un apoptozes procesos eksperimentāla išēmiska insulta subakūtajā stadijā

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RESEARCH PRODUCT

Izmaiņas neironu mielinizācijas un apoptozes procesos eksperimentāla išēmiska insulta subakūtajā stadijā

subject

mielinizācija apoptoze Farmācija fMCAo išēmisks insults

description

Viens no galvenajiem nāves cēloņiem pasaulē ir išēmisks insults. Tā akūtā stadijā novēro apoptozi, programmēto neironu nāvi, kā arī to mielinizācijas traucējumus. Taču trūkst dati par to, vai šie patoloģiskie procesi notiek arī išēmiska insulta subakūtajās stadijās. Šī darba mērķis bija noskaidrot filamenta izraisītas vidējās smadzeņu artērijas oklūzijas (fMCAo) efektus uz apoptozē un neironu mielinizācijā iesaistīto proteīnu (kaspāzes-3 un mielīna bāzes proteīna) ekspresiju kontroles un išēmiska insulta modeļdzīvnieku smadzenēs subakūtā stadijā pēc fMCAo. Rezultāti parāda, ka 2 mēnešus pēc fMCAo išēmiska insulta modeļdzīvnieku išēmijas serdes un penumbra zonā būtiski samazinājusies neironu mielinizācija, savukārt apoptoze netika novērota. Iegūtie dati norāda uz to, ka neironu mielinizācijas traucējumi ir novērojami arī subakūti pēc išēmiska insulta, savukārt apoptoze, visticamāk, norisinās galvenokārt akūtajā stadijā.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54693

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