6533b7ddfe1ef96bd1273912
RESEARCH PRODUCT
Expression of IAPs (Inhibitory of Apoptosis Proteins) and of their alternative splice variants in hepatocellular carcinoma tissues and cells
Monica Notarbartolo Di VillarosaLydia GiannitrapaniMaria MeliPaola PomaLuisa DusonchetGiuseppe MontaltoNatale D'alessandroM Cervellosubject
drug resistanceinhibitors of apoptosis proteinalternative splice varianthepatocellular carcinomaIAPdescription
IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-01 |