6533b7ddfe1ef96bd1273ecd

RESEARCH PRODUCT

Detection of two simultaneous outbreaks of Klebsiella pneumoniae coproducing OXA-48 and NDM-1 carbapenemases in a tertiary-care hospital in Valencia, Spain

Concepción GimenoNuria TormoBegoña FusterC. Salvador

subject

0301 basic medicinemedicine.drug_classKlebsiella pneumoniae030106 microbiologyAntibioticsMicrobiologylcsh:Infectious and parasitic diseasesMicrobiologyresistancecarbapenemase03 medical and health sciencesAntibioticsmedicinelcsh:RC109-216Faecal carriageHospital wardbiologyOutbreaknosocomialTertiary care hospitalbiology.organism_classificationKlebsiella pneumoniae030104 developmental biologyInfectious DiseasesCarriageReduced susceptibilityOriginal Article

description

Klebsiella pneumoniae is one of the most common hospital-acquired Gram-negative pathogens. During the last decade, the emergence of strains with reduced susceptibility or resistance to carbapenems is becoming a therapeutic challenge. This study takes place after the isolation of 14 strains of carbapenem-resistant K. pneumoniae with similar susceptibility patterns and carriage of OXA-48 and NDM-1 carbapenemases genes. Fourteen patients were found to be colonized (faecal carriage) and/or infected by two different clones of carbapenemase-coproducing K. pneumoniae during a 1-year period of time. Some of the patients had shared a hospital ward and continued to be colonized several months after the outbreak. Keywords: Antibiotics, carbapenemase, Klebsiella pneumoniae, nosocomial, resistance

yearjournalcountryeditionlanguage
2020-03-01New Microbes and New Infections
https://doi.org/10.1016/j.nmni.2020.100660