6533b7ddfe1ef96bd1273f5c
RESEARCH PRODUCT
Influence of structural elements on iron(III) chelating properties in a new series of amino acid-derived monohydroxamates
Elzbieta Gumienna-konteckaAgnieszka SzebesczykAgnieszka SzebesczykJenny BesserglickEvgenia Olshvangsubject
chemistry.chemical_classification010405 organic chemistryChemistryStereochemistrySiderophores010402 general chemistry01 natural sciences0104 chemical sciencesAmino acidInorganic Chemistrychemistry.chemical_compoundHydroxamatesFe(III) complexesFunctional groupPolymer chemistryMaterials ChemistrymedicineFerricChelationPhysical and Theoretical ChemistryStoichiometrymedicine.drugdescription
Abstract A series of amino acid-derived monohydroxamate compounds A1 – A7 was synthesized and characterized for their coordination properties of Fe(III). The series varies in their skeletal lengths and compositions; some compounds lack external substituents, others are substituted with external functional amino or carboxylic groups, or alternatively inert methyl. Undertaken investigations allowed the determination of stoichiometry, stability constants and spectroscopic parameters of formed ferric complexes. Incorporation of an external functional group with a dissociable proton affects the coordination behavior; the presence of carboxylic or amino groups hampers the formation of mono-, di- and trihydroxamate ferric complexes of presented compounds. The differences in Fe(III) affinity of the monohydroxamates vs trihydroxamates was reflected by the stability constants and pFe, indicating the superior stability of hexadentate complexes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-03-01 | Inorganica Chimica Acta |