6533b7ddfe1ef96bd1273fe2
RESEARCH PRODUCT
Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.
José P. MartínezW L ChaffinManuel Casanovasubject
medicine.drug_classImmunologyGerm tubeFluorescent Antibody TechniqueMonoclonal antibodyMicrobiologyImmunoglobulin GMicrobiologyImmunoglobulin Fab FragmentsCell WallCandida albicansmedicineAscitic FluidHumansCandida albicansMyceliumMembrane GlycoproteinsbiologyImmunoglobulin Fab FragmentsAntibodies Monoclonalbiology.organism_classificationMolecular biologyYeastInfectious DiseasesMicroscopy FluorescenceImmunoglobulin Gbiology.proteinParasitologyAntibodyResearch Articledescription
Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incubated with Fab fragments but a confluent binding on cells incubated with intact MAb 4C12.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-11-01 | Infection and immunity |