6533b7ddfe1ef96bd1274a07

RESEARCH PRODUCT

Identification of Key miRNAs in Regulation of PPI Networks

Riccardo RizzoGiosuè Lo BoscoMassimo La RosaAlfonso UrsoLaura La PagliaAntonino Fiannaca

subject

Settore ING-INF/05 - Sistemi Di Elaborazione Delle Informazioni0301 basic medicineOptimization problemSettore INF/01 - InformaticaHeuristic (computer science)Computer sciencemiRNA expression profiles Protein-protein interaction networks Genetic algorithmsComputational biologyGenetic algorithmsmiRNA expression profilesProtein-protein interaction networks03 medical and health sciencesIdentification (information)030104 developmental biologyPpi networkGenetic algorithmmicroRNAKey (cryptography)Set (psychology)

description

In this paper, we explore the interaction between miRNA and deregulated proteins in some pathologies. Assuming that miRNA can influence mRNA and consequently the proteins regulation, we explore this connection by using an interaction matrix derived from miRNA-target data and PPI network interactions. From this interaction matrix and the set of deregulated proteins, we search for the miRNA subset that influences the deregulated proteins with a minimum impact on the not deregulated ones. This regulation problem can be formulated as a complex optimization problem. In this paper, we have tried to solve it by using the Genetic Algorithm Heuristic. As the main result, we have found a set of miRNA that is known to be involved in disease development.

yearjournalcountryeditionlanguage
2020-01-01
https://doi.org/10.1007/978-3-030-34585-3_10