6533b7ddfe1ef96bd1274a52
RESEARCH PRODUCT
On-demand autophagic network adaptations upon limited lipid availability
Christian BehlAndreas Kernsubject
0301 basic medicineAutophagy-Related ProteinsGTPaseBiologyModels Biological03 medical and health sciencesLipid dropletAutophagyHumansMolecular Biologychemistry.chemical_classification030102 biochemistry & molecular biologyVesicleAutophagyFatty acidLipid DropletsCell BiologyAdaptation PhysiologicalLipidsCell biologyDe novo synthesis030104 developmental biologychemistryrab GTP-Binding Proteinslipids (amino acids peptides and proteins)RabCommentary and ViewsRAB18description
The de novo synthesis of autophagic vesicles is strongly dependent on sufficient lipid supply. Recently, the RAB GTPase RAB18 was shown to affect autophagy by mediating fatty acid release from lipid droplets, which are lipid sources for autophagosome formation. The stable loss of RAB18 interfered with fatty acid release from the lipid reservoirs and provoked autophagy network adaptations aiming to maintain autophagic activity under lipid limiting conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-04-16 | Autophagy |