Pro-inflammatory CX3CR1+ CD59+ TL1A+ IL-23+ monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions

6533b7ddfe1ef96bd1274f74

RESEARCH PRODUCT

Pro-inflammatory CX3CR1+ CD59+ TL1A+ IL-23+ monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions

Francesco Ciccia Giuliana Guggino Michael Zeng Ranjeny Thomas Vidya Ranganathan Arifur Rahman Riccardo Alessandro Aroldo Rizzo Laura Saieva Federica Macaluso Sergio Peralta Diana Di Liberto Francesco Dieli Paola Cipriani Roberto Giacomelli Dominique Baeten Nigil Haroon

subject

Settore MED/16 - Reumatologia CX3CR1+ monocyte CX3CR1+ monocytes CX3CR1+ monocytes; IL-23; ILC3; TL1A; gut inflammation IL-23 ILC3 TL1A gut inflammation

description

Gut derived ILC3 have been demonstrated to participate in AS pathogenesis. CX3CR1+ mononuclear phagocytes (MNP) have been demonstrated to modulate ILC3 function in the gut. The aim of this study was to study the role of pro-inflammatory CX3CR1+ CD59+ MNP in modulating ILC3 function in AS patients.

year	journal	country	edition	language
2018-06-05

10.1002/art.40582 http://hdl.handle.net/10447/295625

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