6533b7ddfe1ef96bd12753bb

RESEARCH PRODUCT

DNA origami as a nanoscale template for protein assembly

Kimmo T LaitinenAnton KuzykAnton KuzykPäivi Törmä

subject

Materials scienceMechanical EngineeringBioengineeringNanotechnologyDNAGeneral ChemistryNanostructuresComplex proteinMechanics of MaterialsMultiprotein ComplexesDNA nanotechnologyNanotechnologyDNA origamiGeneral Materials ScienceStreptavidinSelf-assemblyProtein MultimerizationElectrical and Electronic EngineeringNanoscopic scale

description

We describe two general approaches to the utilization of DNA origami structures for the assembly of materials. In one approach, DNA origami is used as a prefabricated template for subsequent assembly of materials. In the other, materials are assembled simultaneously with the DNA origami, i.e. the DNA origami technique is used to drive the assembly of materials. Fabrication of complex protein structures is demonstrated by these two approaches. The latter approach has the potential to be extended to the assembly of multiple materials with single attachment chemistry.

yearjournalcountryeditionlanguage
2009-05-19Nanotechnology
https://doi.org/10.1088/0957-4484/20/23/235305