6533b7defe1ef96bd1275915
RESEARCH PRODUCT
Scaffold and scaffold-free self-assembled systems in regenerative medicine.
Thomas D.Gaspar D.Sorushanova A.Milcovich G.Spanoudes K.Mullen A. M.O'brien T.Pandit A.Zeugolis D. I.subject
Modular engineeringTissue EngineeringTissue ScaffoldsCell-assembled devicesSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoBiomimetic MaterialsGuided Tissue RegenerationHumansSelf-assemblyRegenerative MedicineDelivery of biologicsStimuli-responsive polymersExtracellular Matrixdescription
Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes. Biotechnol. Bioeng. 2016;113: 1155-1163. © 2015 Wiley Periodicals, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-06-01 | Biotechnology and bioengineering |