Iekšējās delēcijas saturošu hepatīta B vīrusa kora proteīna variantu raksturojums

6533b7defe1ef96bd1275aa1

RESEARCH PRODUCT

Iekšējās delēcijas saturošu hepatīta B vīrusa kora proteīna variantu raksturojums

Sabīne/sabine Brauna/braun

subject

Dzīvās dabas zinātnes Bioloģija Biology Publikāciju kopa

description

Iekšējās delēcijas saturošu hepatīta B vīrusa kora proteīna variantu raksturojums Kopsavilkums Iekšējās delēcijas saturošiem hepatīta B vīrusa kora gēniem atbilstošo proteīnu izpētei tika izmantota Semliki Forest vīrusa ekspresijas sistēma. Šie HBV kora gēnu varianti sākotnēji tika izolēti no imunosupresētiem nieru transplantācijas pacientiem, kam bija konstatēta aknu saslimšanas galējā fāze. Tika konstatēts, ka iekšējās delēcijas saturošu HBV kora proteīnu intracellulārā uzkrāšanās salīdzinājumā ar dabīgā tipa HBV kora proteīnu ir būtiski samazināta, jo iekšējās delēcijas saturošie kora proteīni tiek ātri degradēti ar proteasomas palīdzību. Turklāt, salīdzinājumā ar dabīgā tipa HBV kora proteīnu tika novērotas atšķirības intracellulārajā lokalizācijā. Iekšējās delēcijas saturošu HB kora proteīnu jutība pret proteasomālo degradācijas ceļu, kā arī atšķirīgais intracellulārā sadalījuma spektrs var ietekmēt šās pacientu grupas patoģenēzi.

year	journal	country	edition	language
2009-01-01

https://dspace.lu.lv/dspace/handle/7/3632

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