6533b7defe1ef96bd1275b1c
RESEARCH PRODUCT
Transcriptional and Epigenetic Control of Astrogliogenesis
Benedikt BerningerNeha Tiwarisubject
0301 basic medicineGeneticsNeurogenesisBiologyNeural stem cell03 medical and health sciences030104 developmental biology0302 clinical medicineHistonemedicine.anatomical_structureDNA methylationmicroRNAbiology.proteinmedicineEpigeneticsNeuroscienceTranscription factor030217 neurology & neurosurgeryAstrocytedescription
Abstract Astrocytes exert pivotal functions in the brain ranging from homeostasis to plasticity and their malfunctioning may contribute to neurodegenerative diseases. With increased recognition of their importance, more efforts are being dedicated to decoding the molecular mechanisms that control the generation of astrocytes from neural stem cells, a process referred to as astrogliogenesis. In this chapter, we highlight the discoveries that have shed light on the role of transcription factors, DNA methylation, histone modifications, and microRNAs in driving the transcriptional programs that underlie astrocyte generation. We further discuss the current understanding of gene regulatory pathways that control the switch from neurogenesis to astrogliogenesis during development.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |