6533b7defe1ef96bd1275bac

RESEARCH PRODUCT

A metal-free and regioselective approach to (Z)-β-fluorovinyl sulfones and their chemoselective hydrogenation to β-fluoroalkyl sulfones

Santos FusteroDaniel M. SedgwickRaquel RománCristina MoralesPablo Barrio

subject

010405 organic chemistryOrganic ChemistryRegioselectivity010402 general chemistry01 natural sciencesBiochemistry0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundchemistryHydrogenation reactionEnvironmental ChemistryOrganic chemistryReactivity (chemistry)Physical and Theoretical ChemistryFluoride

description

Abstract A highly regioselective, metal-free hydrofluorination reaction of alkynyl sulfones was developed using TBAF—one of the cheapest and most commonly available fluoride sources. In addition, the reactivity of the resulting β-fluorovinyl sulfones was studied, focusing on their selective hydrogenation reaction. Both β-fluorovinyl sulfones and their hydrogenation products β-fluoroalkyl sulfones may find applications in medicinal and agrochemical sciences.

yearjournalcountryeditionlanguage
2018-02-01Journal of Fluorine Chemistry
https://doi.org/10.1016/j.jfluchem.2017.12.016