6533b7defe1ef96bd1275c2c
RESEARCH PRODUCT
Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol
Emeric LimagneEmeric LimagneFrançois GhiringhelliFrançois GhiringhelliVirginie AiresVirginie AiresAlessandra ScagliariniAlessandra ScagliariniDidier J. ColinAlexia Karen CotteAlexia Karen CotteDominique DelmasDominique Delmassubject
Programmed cell deathGeneral NeuroscienceLipid microdomainfood and beveragesBiologyResveratrolEndocytosisGeneral Biochemistry Genetics and Molecular BiologyCell biologyCell membranechemistry.chemical_compoundmedicine.anatomical_structureHistory and Philosophy of SciencechemistryApoptosisCancer cellmedicinelipids (amino acids peptides and proteins)Lipid raftdescription
The preventive effects of the phytoalexin trans-resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review, we show the crucial role of cell membrane microdomains, that is, lipid rafts, not solely in the initiation of the early biochemical events triggered by resveratrol leading to cancer cell death, but also in resveratrol absorption and distribution. Resveratrol accumulates in lipid rafts and is then taken up by cells through raft-dependent endocytosis. These events allow early activation of kinase pathways and redistribution of cell death receptors within lipid microdomains, events ultimately leading to apoptotic cell death.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-07-01 | Annals of the New York Academy of Sciences |