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RESEARCH PRODUCT
Selective Formation of 4,4'-Biphenols by Anodic Dehydrogenative Cross- and Homo-Coupling Reaction.
Anton WiebeRolf BreinbauerPhilipp J. KohlpaintnerSiegfried R. WaldvogelBenedikt DahmsDieter Schollmeyersubject
010405 organic chemistryChemistryOrganic ChemistryGeneral Chemistry010402 general chemistryElectrochemistry01 natural sciencesEnvironmentally friendlyCombinatorial chemistryCatalysisCoupling reaction0104 chemical sciencesAnodeReagentOxidizing agentDehydrogenationStoichiometrydescription
A simple and selective electrochemical synthesis by dehydrogenative coupling of unprotected 2,6- or 2,5-substituted phenols to the desired 4,4'-biphenols is reported. Using electricity as the oxidizing reagent avoids pre-functionalization of the starting materials, since a selective activation of the substrates takes place. Without the necessity for metal-catalysts or the use of stoichiometric reagents it is an economic and environmentally friendly transformation. The elaborated electrochemical protocol leads to a broad variety of the desired 4,4'-biphenols in a very simplified manner compared to classical approaches. This is particular the case for the cross-coupled products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-29 | Chemistry (Weinheim an der Bergstrasse, Germany) |