6533b7defe1ef96bd1276681

RESEARCH PRODUCT

Steroidal saponins from Asparagus acutifolius.

Marc SautourMarie Aleth Lacaille-duboisTomofumi Miyamoto

subject

Antifungal AgentsStereochemistryAsparagus acutifoliusSaponinPlant ScienceHorticulturePharmacognosyBiochemistryPlant RootsSteroids HeterocyclicMolecular BiologyCandidachemistry.chemical_classificationbiologyMolecular StructureLiliaceaeHydrolysisGlycosideBiological activityGeneral MedicineSaponinsAntimicrobialbiology.organism_classificationCorpus albicanschemistryAsparagus Plant

description

Abstract Six new steroidal saponins ( 1 – 6 ) were isolated from the roots of A. acutifolius L., together with a known spirostanol glycoside ( 7 ). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS and HRESIMS). Compounds 4 – 7 demonstrated antifungal activity against the human pathogenic yeasts C. albicans , C. glabrata and C. tropicalis with MICs values between 12.5 and 100 μg/ml.

yearjournalcountryeditionlanguage
2007-10-01Phytochemistry
10.1016/j.phytochem.2007.02.033https://pubmed.ncbi.nlm.nih.gov/17449075