Novel genetic risk factors associated with three multifactorial traits and their clinical characteristics in Latvian population

6533b7defe1ef96bd1276b4c

RESEARCH PRODUCT

Novel genetic risk factors associated with three multifactorial traits and their clinical characteristics in Latvian population

Raitis Pečulis

subject

Dzīvās dabas zinātnes Bioloģija Molekulārā bioloģija

description

Koronārā sirds slimība (KSS), diabēts un hipofīzes adenoma (HA) ir multifaktoriālas slimības ar pieaugošu mirstību visā pasaulē. Promocijas darba mērķis ir izpētīt ADORA3 polimorfismu ietekmi uz KSS un GLO1 variantu ietekmi uz diabēta komplikācijām, kā arī HA ģenētiskos cēloņus Latvijas populācijā. Pētījumu laikā atklājās rs35511654 ADORA3 asociācija ar aizsardzību pret KSS, polimorfismam modulējot išēmijas izraisītos bojājumus. Divi GLO1 polimorfismi ir asociēti ar samazinātu Glo1 enzīma aktivitāti, bet rets MEN1 polimorfisms rs2959656 bija būtiski asociēts ar klīniski nozīmīgu HA. Pētījumu rezultāti ir prezentēti četrās zinātniskās publikācijās starptautiski citējamos žurnālos un papildina zināšanas par KSS, diabēta un HA ģenētiskajiem mehānismiem Latvijas populācijā.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/38350

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