6533b81ffe1ef96bd1277357
RESEARCH PRODUCT
Demonstration of retinal afferents in the RCS rat, with reference to the retinohypothalamic projection and suprachiasmatic nucleus.
Mathias SchreckenbergerKarin DeckerUrsula Disque-kaiserStefan Reusssubject
Malemedicine.medical_specialtyCholera ToxinHistologyOptic tractHypothalamusBiologyLateral geniculate nucleusRetinaPathology and Forensic MedicineInternal medicinemedicineAnimalsNeuropeptide YNeuronal transportRetinaAfferent PathwaysSuprachiasmatic nucleusSuperior colliculusRetinal DegenerationGeniculate BodiesRats Inbred StrainsCell BiologyRatsEndocrinologymedicine.anatomical_structureHypothalamusFemaleSuprachiasmatic NucleusRetinohypothalamic tractVasoactive Intestinal Peptidedescription
In the Royal College of Surgeons (RCS) rat, characterized by inherited retinal dystrophy, retinal projections to the brain were studied using anterograde neuronal transport of cholera toxin B subunit upon injection into one eye. The respective immunoreactivity was found predominantly contralateral to the injection site in the lateral geniculate nucleus, superior colliculus, nucleus of the optic tract, medial terminal nucleus of the accessory optic tract, and bilateral hypothalamic suprachiasmatic nuclei. Although terminal density was somewhat reduced in dystrophic rats, the projection patterns in these animals appeared similar to those seen in their congenic controls and were comparable to the visual pathways described for the rat previously. In dystrophic rats, the number of cell bodies exhibiting immunoreactivity to vasoactive intestinal polypeptide, viz. a population of suprachiasmatic neurons receiving major retinohypothalamic input, was reduced by one-third, and some differences were observed in the termination pattern of the geniculohypothalamic tract, as revealed by immunoreactivity to neuropeptide Y in the suprachiasmatic nucleus.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-12-01 | Cell and tissue research |