6533b81ffe1ef96bd1277371

RESEARCH PRODUCT

The STATe of the Neuron Leads to Synaptic Stripping

Alma N. MohebianyAri Waisman

subject

Neurons0301 basic medicinePhagocytesChemistryT-LymphocytesGeneral NeuroscienceCellCCL2Viral infectionMonocytes03 medical and health sciences030104 developmental biologymedicine.anatomical_structureStripping (linguistics)medicineNeuronNeuroscienceChemokine CCL2

description

In a recent issue of Cell, Di Liberto et al. (2018) elucidate the mechanisms involved in synaptic stripping during viral infection. Infected neurons orchestrate their own synaptic loss downstream of IFNγ signaling, ultimately attracting phagocytic monocytes into the CNS through CCL2 production.

yearjournalcountryeditionlanguage
2018-10-12Neuron
https://doi.org/10.1016/j.neuron.2018.09.036