6533b81ffe1ef96bd12777de

RESEARCH PRODUCT

Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma : a preliminary study

Jose V. BaganY. JiménezJ. MurilloR. PovedaJ. M. DiazC. GavaldáM. MargaixC. ScullyT. M. AlberolaM. Torres PuenteM. Pérez Alonso

subject

stomatognathic diseaseshemic and lymphatic diseasesUNESCO::CIENCIAS MÉDICAS:CIENCIAS MÉDICAS [UNESCO]

description

The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of SubGroup 3 (controls).

yearjournalcountryeditionlanguage
2008-01-01
http://hdl.handle.net/10550/60708