6533b81ffe1ef96bd1277a71

RESEARCH PRODUCT

Mode of interaction of different polyanions with the first (), the second (C2) and the fourth (C4) component of complement—II

Michael LoosMichael LoosRobert M. StroudRobert M. StroudJohn E. VolanakisJohn E. Volanakis

subject

Complement component 2StereochemistryChemistryMagnesiumRehabilitationtechnology industry and agriculturechemistry.chemical_elementPhysical Therapy Sports Therapy and Rehabilitationmacromolecular substancesGeneral MedicineHeparinMedicinal chemistryDissociation (chemistry)SulfationDextran sulfatePolyvinyl sulfatemedicinemedicine.drug

description

Abstract Dextran sulfate, polyvinyl sulfate, liquoid, heparin and Sp 54, ∗ (a pentosanpoly-sulfoester) prevented the uptake of C2 by EAC4b. In contrast to EAC 4 b 2 a , treatment of EAC4b2 with polyanions led to dissociation into EAC4b and C2. The inhibition of C2 uptake by polyanions could be reduced by increasing magnesium concentration to levels which are normally inhibitory, suggesting that Mg ++ ions are sequestered by these sulfated polyanions.

yearjournalcountryeditionlanguage
1976-03-01Immunochemistry
https://doi.org/10.1016/0019-2791(76)90224-x