6533b81ffe1ef96bd1277aa6

RESEARCH PRODUCT

Caretakers and Gatekeepers

Viviana BazanR. MaraglianoAntonio RussoDaniele Fanale

subject

0301 basic medicineGeneticsCellCaretaker geneCell cycleBiologyInformation integritylaw.invention03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structureApoptosislaw030220 oncology & carcinogenesismedicineSuppressorTumor growthGene

description

It has now been generally accepted that the genes responsible for familial cancer syndromes can be divided into two categories, known as caretakers and gatekeepers. Caretakers are genes that control the maintenance of the genetic information integrity in each cell while gatekeepers are those genes which directly regulate tumor growth, codifying for proteins which either stimulate or inhibit proliferation, differentiation or apoptosis. Keywords: gatekeeper genes; caretaker genes; tumor suppressor genes; cell cycle; hereditary syndromes

yearjournalcountryeditionlanguage
2017-09-15eLS
https://doi.org/10.1002/9780470015902.a0006048.pub2