Sigma 1 receptora ietekme uz peļu mezenhimālo stromas šūnu osteodiferenciāciju

6533b81ffe1ef96bd1277fb6

RESEARCH PRODUCT

Sigma 1 receptora ietekme uz peļu mezenhimālo stromas šūnu osteodiferenciāciju

subject

osteodiferenciācija Sigma-1 receptors Farmācija stromālā vaskulārā frakcija gēnu ekspresija mezenhimālās stromas šūnas

description

Mezenhimālajām stromas šūnām (MSŠ) piemīt osteodiferenciācijas potenciāls. Sigma-1 receptors (SigmaR1) ir transmembrānu proteīns, tā ietekme uz osteodiferenciāciju nav vēl zināma. Bakalaura darba mērķis bija noskaidrot SigmaR1 ietekmi uz peļu taukaudu MSŠ (T-MSŠ) osteodiferenciāciju. Osteodiferenciācijas norise un SigmaR1 ietekme uz osteodiferenciāciju tika analizēta, pētot osteoģenēzē iesaistīto gēnu ekspresiju peļu T-MSŠ ar qPCR metodi. Salīdzinot izslēgta SigmaR1 (S1R-/-) T-MSŠ pret WT (wild type) T-MSŠ gēnu ekspresiju pēc osteodiferenciācijas, transkripcijas faktora osterix ekspresija tika nozīmīgi palielināta, bet nediferencētā stāvoklī būtiskas izmaiņas netika novērotas.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54673

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