6533b81ffe1ef96bd1278399

RESEARCH PRODUCT

IMMUNOLOGICAL ASPECTS OF CROHN'S DISEASE: A REGULATORY FUNCTION OF TIM-3/GALECTIN-9 IN LYTH1.

Francesco CariniC GagliardoM MazzolaE Lo PrestiM ScaglioneA JurjusAg GeageaR ZerbeAngelo LeoneFrancesca RappaSabrina DavidGiovanni Tomasello

subject

Settore MED/18 - Chirurgia GeneraleChrohn's disease inflammatory boewel diseases TIM-3/GALECTIN-9.

description

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic environmental factors. The interaction of these factors causes an imbalance of the microbiota, leading to the activation of several immunological and inflammatory mechanism. From an immunological point of view, there seems to be an involvement of the TIM-3/GALECTIN-9 pathway and of the autoregulation of lyTh1. These studies show that in patients with CD the autoregulation of lyth1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reason for the state of perpetual activation of lyTh1, resulting in the chronic inflammation process.

yearjournalcountryeditionlanguage
2017-01-01
10.3269/1970-5492.2017.12.14http://hdl.handle.net/10447/234546