Cholestenon in Rattennebennieren

6533b81ffe1ef96bd1278499

RESEARCH PRODUCT

Cholestenon in Rattennebennieren

subject

medicine.medical_specialty medicine.drug_class Endogeny In vitro incubation Rat Adrenals Tissue cholesterol chemistry.chemical_compound Endocrinology Biosynthesis chemistry Internal medicine Adrenal tissue medicine Corticosteroid

description

For the first time it has been proven that cholest-4-ene-3-one is an endogenous constituent of adrenal tissue. Concentrations of cholestenone in quartered rat adrenals after 3 hours of in vitro incubation were comparable to those of progesterone. However, from specific radioactivities of tissue cholesterol and progesterone and from those of tissue cholestenone and progesterone after incubations with either 4-14C-cholesterol or 4-14C-cholestenone it has been concluded that, at best, cholestenone plays a minimal role as a C27-intermediate of corticosteroid biosynthesis.

year	journal	country	edition	language
1970-01-01

https://doi.org/10.1007/978-3-642-80591-2_101

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