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RESEARCH PRODUCT
A Step into the Future: Applications of Nanoparticle Enzyme Mimics.
Wolfgang TremelMuhammed Nawaz TahirKarsten Korscheltsubject
chemistry.chemical_classificationHigh rateBiomoleculeOrganic ChemistryIrregular shapeNanoparticleProteinsNanotechnology02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesCatalysis0104 chemical sciencesNanomaterialsEnzymesEnzymechemistryBiomimeticsCoordination ComplexesNanoparticlesNanotechnology0210 nano-technologyInorganic nanoparticlesdescription
We describe elementary concepts, up-to-date developments, and perspectives of the emerging field of nanoparticle enzyme mimics (so-called "nanozymes") at the interface of chemistry, biology, materials, and nanotechnology. The design and synthesis of functional enzyme mimics is a long-standing goal of biomimetic chemistry. Metal complexes, polymers and engineered biomolecules capturing the structure of natural enzymes or their active centers have been made to achieve high rates and enhanced selectivities. Still, the design of new "artificial enzymes" that are not related to proteins but with capacity of production and stability at industrial level, remains a goal. Inorganic nanoparticles bear this potential. Although it seems counterintuitive to compare nanoparticles and natural enzymes because they appear very different they share many common features: nano-size, irregular shape, and rich surface chemistry. These features enable nanomaterials to mimic reactions of natural enzymes. Representative examples with biomedical and environmental applications are given.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-04-26 | Chemistry (Weinheim an der Bergstrasse, Germany) |