6533b81ffe1ef96bd1278782
RESEARCH PRODUCT
Bafouoside C, a new triterpenoid saponin from the roots of Cussonia bancoensis Aubrev. & Pellegr.
Marie Aleth Lacaille-duboisAzefack Léon TapondjouLuciano BarboniRaymond Ngansop NonoRémy Bertrand TeponnoBeaudelaire Kemvoufo PonouBeaudelaire Kemvoufo PonouMassimo BramucciLuana Quassintisubject
chemistry.chemical_classificationbiologyCussoniaStereochemistryPlant Sciencebiology.organism_classificationBiochemistryNmr datachemistryCarcinoma CellAraliaceaeAgronomy and Crop ScienceHuman breastTwo-dimensional nuclear magnetic resonance spectroscopyHuman colonBiotechnologyTriterpenoid saponindescription
Abstract A new triterpenoid saponin named bafouoside C 3-O-β- d -glucopyranosyl-(1 → 4)-[β- d -galactopyranosyl-(1 → 2)]-β- d -glucuronopyranosyloleanolic acid 28-O-β- d -glucopyranosyl ester; (1), together with five known compounds 3-O-β- d -galactopyranosyl-(1 → 2)-β- d -glucuronopyranosyloleanolic acid (2), 23-hydroxyursolic acid (3), 28-O-α- l -rhamnopyranosyl-(1 → 4)-O-β- d -glucopyranosyl-(1 → 6)-O-β- d -glucopyranosyl-23-hydroxyursolic acid (4), 3-O-β- d -glucopyranosyl-23-hydroxyursolic acid (5), and 3-O-α- l -arabinopyranosyl-23-hydroxyursolic acid (6), were isolated from the roots of Cussonia bancoensis Aubrev. & Pellegr. Their structures were established on the basis of 1D- and 2D NMR data, mass spectrometry and chemical methods. The NMR data of the known compounds, as far as we know, are herein reported for the first time in CD3OD. Compound 3 exhibited a weak cytotoxic activity against MDA-MB 231 human breast adenocarcinoma, A375 human malignant melanoma, and HCT116 human colon carcinoma cell lines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-12-01 |