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RESEARCH PRODUCT

The first example of natural cyclic carbonate in terpenoids

Gabriella BelloneSergio RosselliAntonella MaggioMaurizio Bruno

subject

StereochemistryOrganic ChemistrySESQUITERPENE LACTONESBiochemistryDiacetylTerpenoidGUAIANOLIDESchemistry.chemical_compoundchemistryDrug DiscoveryOrganic chemistryCarbonateCONSTITUENTSDerivative (chemistry)

description

Abstract The first natural occurring cyclic carbonate terpenoid, the guaianolide hololeucin ( 1 ), was isolated from the aerial part of Centaurea hololeuca . Its structure was elucidated on the basis of extensive proton, 13 C and two-dimensional NMR experiments, as well as by transformation in its diacetyl derivative.

https://doi.org/10.1016/j.tetlet.2006.07.099