6533b81ffe1ef96bd127889d
RESEARCH PRODUCT
Virion Antigens Introduced Exogeneously into the Cell Membrane Render Syngeneic Target Cells Susceptible for T Cell-Mediated Cytolysis
Martin RöllinghoffA Starzinski-powitzHermann WagnerKlaus Pfizenmaiersubject
Cytotoxicity ImmunologicMacrophagesT-LymphocytesvirusesGeneral MedicineBiologybiology.organism_classificationMolecular biologyVirusSendai virusParainfluenza Virus 1 HumanCell membraneMiceCytolysismedicine.anatomical_structureImmune systemAntigenLytic cycleAntibody SpecificityHistocompatibility AntigensMice Inbred CBAmedicineAnimalsCytotoxic T cellAntigens Viraldescription
Non-infectious sendai virus renders H-2 matched target cells susceptible to the lytic effect of sendai virus immune cytotoxic T lymphocytes. This observation suggests that exogeneous insertion of virion antigen in the membrane of the target cell is sufficient for T cell cytotoxicity. The finding is incompatible with the concept that H-2K or H-2D gene products of the target cells must be altered in their primary structure (pretranslational effect of the virus infection) for T cell-mediated cytolysis to occur.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1977-09-01 | Zeitschrift für Immunitätsforschung: Immunobiology |