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RESEARCH PRODUCT

Synthesis of umbellifolide and three natural eudesman-12,8-olides from (-)-artemisin

Miguel CardaJ. Alberto Marco

subject

ChemistryOrganic ChemistryDrug DiscoveryOrganic chemistryBiochemistry

description

Abstract The syntheses of the natural 4,5-secoeudesmanolide 1 (umbellifolide) and the eudesmanolides 2, 3 and 4 are described. The starting materials are synthetic eudesmane derivatives, the preparation of which from (-)-artemisin had been previously reported.

https://doi.org/10.1016/s0040-4020(01)81659-8