Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.

6533b81ffe1ef96bd1278f29

RESEARCH PRODUCT

Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.

Clelia Giannini Cécile Debitus Miguel Payá Maria Valeria D'auria Inmaculada Posadas

subject

chemistry.chemical_classification biology Stereochemistry Chemical structure Organic Chemistry biology.organism_classification Biochemistry Sponge Manoalide chemistry.chemical_compound Enzyme Phospholipase A2 chemistry Biochemistry Drug Discovery biology.protein Potency Selectivity IC50

description

Abstract A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A2 (PLA2) at 10 μM, with an IC50 value of 2.6 μM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.

year	journal	country	edition	language
2000-04-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(00)00362-2

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