6533b81ffe1ef96bd1278f3e
RESEARCH PRODUCT
Enantioselective Synthesis of Substituted Indoles Through Zirconium(IV)-Catalyzed Friedel–Crafts Alkylation
Isabel FernándezGonzalo BlayCarlos VilaJosé R. Pedrosubject
chemistry.chemical_classificationZirconiumOrganic ChemistryEnantioselective synthesischemistry.chemical_elementAlkylationMedicinal chemistryCatalysisStereocenterchemistryMichael reactionSide chainFriedel–Crafts reactionAlkyldescription
The chiral complex of ( R )-3,3′-Br 2 -BINOL and zirconium tert -butoxide catalyzes the Friedel–Crafts alkylation of indoles with enones bearing an alkyl or fluorinated group at the β-position to give indoles having a side chain at the C3 position with a tertiary stereogenic center in good yields and with excellent enantioselectivities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-08-23 | Synthesis |