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RESEARCH PRODUCT
Role of apoptosis in autoimmunity.
Ann ZeunerMatilde TodaroGiorgio Stassisubject
Multiple SclerosisbiologyImmunologyThyroiditis AutoimmuneApoptosisAutoimmunitymedicine.disease_causeapoptosiGraves DiseaseAutoimmunityAutoimmune DiseasesPathogenesisDiabetes Mellitus Type 1Basic researchApoptosisImmunologybiology.proteinMolecular mechanismmedicineImmunology and AllergyDeath ReceptorsAnimalsHumansAntibodydescription
Autoimmune diseases are characterized by the activity of autoreactive lymphocytes that produce antibodies targeting self tissue or organ for destruction. Although the pathogenesis of these diseases is poorly understood, during the past two decades basic research has indicated apoptosis as the pivotal molecular mechanism leading to autoimmunity. Recently cytokines have been invoked in the regulation of the apoptosis-related factors and death receptors in autoimmune target destruction. These research advances have contributed to the identification of mechanisms controlling autoimmunity for defining novel therapeutic strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-03-05 | Journal of clinical immunology |