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RESEARCH PRODUCT
ChemInform Abstract: Catalytic Enantioselective Friedel—Crafts Alkylation at the 2-Position of Indole with Simple Enones.
Isabel FernándezCarlos VilaGonzalo BlayJosé R. Pedrosubject
Indole testZirconiumChemistryEnantioselective synthesischemistry.chemical_elementGeneral MedicineAlkylationBenzoquinoneMedicinal chemistryFriedel–Crafts reactionCatalysisdescription
Abstract A procedure for the enantioselective alkylation of indole at the 2-position with simple non-chelating enones is described for the first time. Reaction between 4,7-dihydroindole and enones in the presence of zirconium(IV)–BINOL complexes, followed by a p -benzoquinone oxidation gives indoles alkylated at the 2-position with good yields and moderate enantioselectivities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-08 | ChemInform |