6533b820fe1ef96bd127a4d1
RESEARCH PRODUCT
Resistive index of ophthalmic artery as an imaging biomarker of hypertension-related vascular and kidney damage
Alessandro MattinaAlessandro MattinaAntonina GiammancoGiuseppe MulèMarta Maria ZammutoFabio TuzzolinoMaurizio AvernaGiulio GeraciCarlo MaidaEmilio NardiSantina Cottonesubject
AdultCarotid Artery DiseasesMalemedicine.medical_specialtyhypertensionSettore MED/09 - Medicina InternaImaging biomarkerClinical BiochemistryHemodynamicsDiseaseKidneyCarotid Intima-Media ThicknessalbuminuriaMicrocirculationcarotid intima-media thickneRisk FactorshemodynamicInternal medicinemedicine.arteryDrug DiscoverymedicineHumansAgedSettore MED/14 - NefrologiaKidneybusiness.industryBiochemistry (medical)Ultrasonography DopplerMiddle AgedResistive indexmedicine.anatomical_structureCardiovascular DiseasesOphthalmic arteryCardiologyAlbuminuriaFemaleKidney Diseasesophthalmic arterymedicine.symptombusinessBiomarkersdescription
Aim: Resistive index of ophthalmic artery (RI-OA) is associated with atherosclerotic diseases. The aim of this study was to evaluate the association of RI-OA and hypertension-related vascular and kidney damage. Materials and methods: Two-hundred and eighty hypertensive patients underwent evaluation of RI-OA, carotid atherosclerosis and level of 24 h albuminuria. Results: Albuminuria and carotid atherosclerosis were positively associated with RI-OA independently of other cardiovascular risk factors. Receiver-operating characteristic curve analysis allowed us to calculate a cut-off value of RI-OA >0.625, which would be suspicious about the existence of atherosclerotic disease. Conclusion: The ophthalmic vascular circulation allows to study connections between macro- and microcirculation in vivo. RI-OA could be a useful marker for a better stratification of the risk of developing kidney and cardiovascular disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-01 |