6533b820fe1ef96bd127a697

RESEARCH PRODUCT

Targeting the Sortase A Transpeptidase to Tackle Gram-positive Pathogens

subject

description

The virulence factors include the cell-wall associated proteins called MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) that can promote the adhesion to host proteins, for example, the fibronectin that is very common in host tissues. The cellwall associated proteins are necessary for host colonization, invasion, immune evasion and biofilm formation [4]. The biofilms, multistratified bacterial communities that grow on a biological or artificial surface, are responsible for chronic infectious diseases and for device or biomaterial associated infections, and are more resistant to host immune defence system and to conventional antibiotics [5].