6533b820fe1ef96bd127a6b2

RESEARCH PRODUCT

Lack of effect of azithromycin on QT interval in children: a cohort study.

Silvia CastilloMarcela MorenoAmparo EscribanoDavid Espadas

subject

Malemedicine.medical_specialtyDrug-Related Side Effects and Adverse ReactionsRespiratory Tract DiseasesErythromycin030204 cardiovascular system & hematologyAzithromycinAzithromycinQT intervalCardiovascular deathCardiovascular Physiological PhenomenaCohort Studies03 medical and health sciences0302 clinical medicineClarithromycinInternal medicinemedicineHumans030212 general & internal medicineIntensive care medicineChildbusiness.industryAntimicrobialAnti-Bacterial AgentsLong QT SyndromeTreatment OutcomeSpainPharmacodynamicsPediatrics Perinatology and Child HealthChronic DiseaseFemalebusinessElectrophysiologic Techniques Cardiacmedicine.drugCohort study

description

Macrolides are a group of antimicrobial drugs used widely, being well known for their adverse cardiac effects. Erythromycin and clarithromycin are most commonly associated with these conditions. In recent years, azithromycin (AZM) has been assessed because of its possible relation to arrhythmias (mainly QT interval prolongation) and risk of cardiovascular death.1 The pharmacodynamics of these effects is complex and the occurrence of cardiovascular death is unpredictable.2 However, all published manuscripts on the cardiac effects of AZM to date are cases in adults or …

yearjournalcountryeditionlanguage
2016-08-11Archives of disease in childhood
10.1136/archdischild-2016-310956https://pubmed.ncbi.nlm.nih.gov/27515186