Mezenhimālo stromas šūnu osteoģenēzes raksturojums uz amorfā kalcija fosfāta biomateriāla

6533b820fe1ef96bd127a818

RESEARCH PRODUCT

Mezenhimālo stromas šūnu osteoģenēzes raksturojums uz amorfā kalcija fosfāta biomateriāla

subject

osteokalcīns osteoģenēze amorfais kalcija fosfāts Farmācija mezenhimālās stromas šūnas

description

Mezenhimālās stromas šūnas ir plaši pētīts šūnu veids to potenciālo ārstniecisko efektu dēļ, no kuriem populārākie ir imūnmodulācija un audu reģenerācija. Bakalaura darbs bija fokusēts uz mezenhimālo stromas šūnu pielietojumu kaulaudu reģenerācijā un to biosaderību ar amorfo kalcija fosfātu, kas organismā atrodams kaula veidošanās sākumstadijā. Darba mērķis bija raksturot uz amorfā kalcija fosfāta biomateriāla audzētu mezenhimālo stromas šūnu osteoģenēzes potenciālu. Osteoģenēzes raksturošanai izmantoja osteokalcīna imūnfluorescento iezīmēšanu, savukārt, biosaderību analizēja ar kolorimetrisko CKK-8 analīzi. Rezultāti uzrādīja, ka mezenhimālas stromas šūnas ir spējīgas augt uz biomateriāla, tomēr to osteoģenēzē lielāka loma ir barotnes sastāvam nevis biomateriāla klātbūtnei.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54682

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