6533b821fe1ef96bd127ad82

RESEARCH PRODUCT

Chromatographic evaluation of the toxicity in fish of pesticides

Rosa María Villanueva-camañasSalvador SagradoMaría José Medina-hernándezJ.m. Bermúdez-saldañaLaura Escuder-gilabert

subject

Quantitative structure–activity relationshipChromatographyToxicity dataChemistryClinical BiochemistryFishesQuantitative Structure-Activity RelationshipCell BiologyGeneral MedicinePesticideBiochemistryAcute toxicityAnalytical ChemistryEnvironmental chemistryToxicityAnimalsFish <Actinopterygii>Spectrophotometry UltravioletPesticidesEcotoxicityChromatography Liquid

description

Abstract Ecotoxicity assessment is essential before placing new chemical substances on the market. An investigation of the use of the chromatographic retention (log k) in biopartitioning micellar chromatography (BMC) as an in vitro approach to evaluate the toxicity in fish of pesticides (acute toxicity levels as pLC50) is proposed. A heterogeneous data set of 85 pesticides from six chemical families with available experimental fish toxicity data (ECOTOX database from U.S. Environmental Protection Agency (EPA)) was used. For pesticides exhibiting non-polar narcosis mechanism in fish (non-specific toxicity), more reliable models and precise pLC50 estimations are obtained from log k (quantitative retention–activity relationships, QRAR) than from log P (quantitative structure-activity relationships, QSAR) or ECOSAR (ECOSAR program from U.S. EPA).

yearjournalcountryeditionlanguage
2004-07-27Journal of Chromatography B
https://doi.org/10.1016/j.jchromb.2004.10.007