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RESEARCH PRODUCT
Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity.
Gaetano DattoloAntonino LauriaPatrizia DianaFrancesco Dall'acquaPaola BarrajaAlessandra MontalbanoGirolamo CirrincioneAnna Maria AlmericoGiampietro Violasubject
StereochemistryFibrosarcomaClinical BiochemistryPharmaceutical ScienceAntineoplastic AgentsQuinolonesRing (chemistry)BiochemistryChemical synthesischemistry.chemical_compoundStructure-Activity RelationshipDrug DiscoveryTumor Cells CulturedPhenyl groupHumansPhotosensitizerPyrrolesMolecular BiologyPhotosensitizing AgentsChemistryOrganic ChemistryGeneral MedicineIn vitroHuman tumorPhotochemotherapyCell cultureLactamMolecular MedicineDrug Screening Assays Antitumordescription
A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-07-23 | Bioorganicmedicinal chemistry letters |