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RESEARCH PRODUCT
Guanidinoacetic Acid as a Nutritional Adjuvant to Multiple Sclerosis Therapy
Sergej M. Ostojicsubject
Behavioral NeurosciencePsychiatry and Mental healthNeuropsychology and Physiological PsychologyNeurologyVDP::Medisinske Fag: 700::Helsefag: 800Biological Psychiatrydescription
Tackling impaired bioenergetics in multiple sclerosis (MS) has been recently recognized as an innovative approach with therapeutic potential. Guanidinoacetic acid (GAA) is an experimental nutrient that plays a significant role in high-energy phosphate metabolism. The preliminary trials suggest beneficial effects of supplemental GAA in MS, with GAA augments biomarkers of brain energy metabolism and improves patient-reported features of the disease. GAA can also impact other metabolic footprints of MS, including demyelination, oxidative stress, and GABA-glutamate imbalance. In this mini-review article, we summarize studies evaluating GAA effectiveness in MS, explore mechanisms of GAA action, and discuss the challenges of using dietary GAA as an element of MS therapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-02-08 |