2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action

6533b821fe1ef96bd127b2f4

RESEARCH PRODUCT

2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action

Demetrio Raffa Benedetta Maggio Fabiana Plescia Stella Maria Cascioferro Maria Valeria Raimondi Maria Grazia Cusimano Domenico Schillaci Giuseppe Daidone G Amico C Carollo Conaldi P.

subject

2-cinnamamidobenzamides 2-(3-phenylpropiolamido)benzamides 2-(3-phenylpropanamido)benzamides antiproliferative activity apoptosis.Settore BIO/19 - Microbiologia Generale Settore CHIM/08 - Chimica Farmaceutica

description

Several new 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides were synthesized by stirring in pyridine the opportune acid chlorides with the appropriate anthranilamide derivatives. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

year	journal	country	edition	language
2013-01-01

http://hdl.handle.net/10447/79425

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