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RESEARCH PRODUCT
Enzyme-mediated enantioselective acylation of secondary amines in organic solvents
J. Alberto MarcoCecilia AndreuGregorio Asensiosubject
chemistry.chemical_classificationbiologyOrganic ChemistryEnantioselective synthesisTriacylglycerol lipaseSubstrate (chemistry)AlcoholBiochemistryCatalysisAcylationchemistry.chemical_compoundEnzymechemistryDrug Discoverybiology.proteinOrganic chemistryLipasedescription
Abstract Porcine pancreatic lipase (PPL) and lipase Amano P catalyze the enantioselective acylation of cyclic 1,2- and 1,3-amino alcohol derivatives in organic solvents. The enatiomeric excesses (ee′s) were shown to depend on the enzyme, reaction time, temperature and type of substrate.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-08-01 | Tetrahedron Letters |