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RESEARCH PRODUCT
Quantitative retention- and migration-toxicity relationships of phenoxy acid herbicides in micellar liquid chromatography and micellar electrokinetic chromatography
M.j. Medina-hernándezSalvador SagradoMaría Luisa MarinaYolanda Martín-bioscaRosa María Villanueva-camañasLaura Escuder-gilabertsubject
ChromatographybiologyChemistrymacromolecular substancesReversed-phase chromatographybiology.organism_classificationBiochemistryDaphniaMicellar electrokinetic chromatographyAnalytical ChemistryAquatic toxicologyMicellar liquid chromatographyMicellar solutionsEnvironmental ChemistryOrganic chemistryQuantitative analysis (chemistry)Chronic toxicitySpectroscopydescription
Abstract The need to obtain a tool for estimation of toxicity parameters for chemicals supports, the postulation of predictive models as an alternative to conventional classical assays. The use of micellar solutions of Brij35 as mobile phases in reversed phase liquid chromatography has proven to be valid in predicting some biological activities of different kinds of drugs. In this paper, the correlations between retention of phenoxy acids using different concentrations of Brij35 as micellar mobile phase in micellar liquid chromatography (MLC) and migration in micellar electrokinetic chromatography (MEKC) with several toxicity parameters are studied. Adequate correlations retention- and migration-toxicity (LC 50 in fish, daphnia and mysid shrimp, EC 50 in green algae and daphnia, and values of chronic toxicity in fish and green algae) of phenoxy acids are obtained. The approach proposed in this paper, involving quantitative retention- and migration-toxicity relationships (QRAR and QMAR) can be very useful in the development of new phenoxy acid herbicides.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-09-01 | Analytica Chimica Acta |