6533b821fe1ef96bd127b818

RESEARCH PRODUCT

Synthesis of the new oligopeptide pyrrole derivative isonetropsin and its one pyrrole unit analogue

Paola BarrajaGirolamo CirrincioneAnna CarbonePatrizia DianaAlessandra MontalbanoVirginia SpanòBarbara Parrino

subject

OligopeptideStereochemistryOrganic ChemistryNetropsinBiochemistryPyrrole derivativesDNA minor groove binderchemistry.chemical_compoundDNA minor groove binderschemistryNetropsinmental disordersDrug DiscoveryNetropsin; DNA minor groove binders; Isonetropsin; Oligopeptide pyrroleAmine gas treatingOligopeptide pyrrolepsychological phenomena and processesIsonetropsinPyrrole

description

We have designed and synthesized isonetropsin and its one pyrrole unit analogue in which the amine and carbonyl groups have been switched in positions 2 and 4, respectively instead of 4 and 2 positions of the natural antibiotic netropsin.

yearjournalcountryeditionlanguage
2013-03-01Tetrahedron
https://doi.org/10.1016/j.tet.2013.01.076