6533b821fe1ef96bd127b8bc

RESEARCH PRODUCT

Autoimmunity seen through the SEREX-scope.

ÖZlem TüreciMichael O. KurrerUgur SahinPhilippe KrebsBurkhard LudewigBurkhard Ludewig

subject

B-LymphocytesRecombinant expressionImmunologyAutoantibodyAutoimmunityBiologymedicine.disease_causeRecombinant ProteinsAutoimmunitySerologyAutoimmune DiseasesMiceImmune systemImmunizationAntigenImmunologyScreening methodmedicineImmunology and AllergyAnimalsHumansImmunizationSerologic TestsAutoantibodies

description

Autoantibodies can be detected in autoimmune diseases with a long prodromal phase and may serve as early indicators of disease activity. Autoantibody-based screening methods are therefore potent tools for the identification of target antigens. The SEREX method (serological identification of antigens by recombinant expression cloning) has been developed for the serological definition of immunogenic tumor antigens. Recent studies indicate that the SEREX approach may also be utilized for the analysis of complex immune responses involved in autoimmune diseases.

yearjournalcountryeditionlanguage
2003-10-11Autoimmunity reviews
10.1016/s1568-9972(03)00047-8https://pubmed.ncbi.nlm.nih.gov/14550875